Transactions of Nonferrous Metals Society of China The Chinese Journal of Nonferrous Metals

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Transactions of Nonferrous Metals Society of China

Vol. 31    No. 12    December 2021

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Comparison of nickle release and cytocompatibility between porous and dense NiTi alloy
Ben-quan YU1, Wen-hui YUAN1, Qiang XU2, Yun-fang-zi GU1, Ming-ming XIAO1, Guo-fu XU2, Zhou LI2, Zhu XIAO2, Zi-an XIAO1

1. Department of Otolaryngology Head and Neck Surgery of Second Xiangya Hospital, Central South University, Changsha 410011, China;
2. School of Materials Science and Engineering, Central South University, Changsha 410083, China

Abstract:The porous NiTi (pNiTi) samples were produced by sintering evaporation using Ti-50.8Ni (at.%) gas- atomized powders. The samples were analyzed by metallographic microscope and X-ray dispersive spectroscopy (XRD). A comparison of nickel (Ni) release and cytocompatibility between pNiTi and dense NiTi (dNiTi) was made. The results showed that the pNiTi has good mechanical properties. Ni releases from pNiTi in vitro and in vivo are more serious than those form dNiTi. The proliferation and differentiation of cells cultured with the pNiTi extracting liquid are significantly worse, and the rate of early apoptosis is higher. In conclusion, pNiTi is mechanically similar to bone, but pNiTi releases more Ni and interferes with cell proliferation and differentiation. A significantly cautious approach should be adopted when using it as a medical implant.


Key words: porous nitinol alloy; mechanical property; nickel release; cytocompatibility

ISSN 1004-0609
CN 43-1238/TG

ISSN 1003-6326
CN 43-1239/TG

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